My Friend's Little Sister Has It In for Me! (2025)
A 2025 anime comedy series about a self-proclaimed efficiency-obsessed high schooler whose orderly life is gleefully dismantled by one unstoppably clingy girl.
My Friend's Little Sister Has It In for Me! - Series Information
- Original Title: 友達の妹が俺にだけウザい
- First Air Year: 2025
- Last Air Year: 2025
- Type: TV Series
- Genres: Animation, Comedy
- Content Rating (US): TV-14
- Episode Runtime: Average runtime per episode: 23 minutes
- Number of Seasons: 1
- Number of Episodes: 12
- Status: Ended
- Original Language: Japanese
- Spoken Languages: Japanese
- First Air Date: October 4, 2025 (United States - TV-14), October 4, 2025 (Australia - M)
- Networks: HTB, tv asahi, Nagoya TV, KBC, ABC TV, NCC, OAB, ABA, Niigata Television Network 21, khb, KFB, HOME, KSB, Kagoshima Broadcasting, Iwate Asahi TV, Akita Asahi Broadcasting, Yamagata Television System, Shizuoka Asahi TV, Asahi Broadcasting Nagano, Hokuriku Asahi Broadcasting, Ehime Asahi TV, Yamaguchi Asahi Broadcasting, Kumamoto Asahi Broadcasting, Ryu-Q Asahi Broadcasting
- Alternative Titles: いもウザ (JP), 朋友的妹妹只喜欢烦我 (CN), My Friend's Little Sister is Annoying Only Towards Me (US)
- Production Companies: BLADE, NK Animation, Asmik Ace, SB Creative, PIA Corporation, BS11, TV Asahi, TV Asahi Music, Square Enix
- Production Countries: Japan
My Friend's Little Sister Has It In for Me! - Plot
For high schooler Akiteru Oboshi, the whole youthful experience thing—like fun, friendships, and even having a girlfriend—is a complete waste of time. So when his best friend's sister, Iroha Kohinata, keeps teasing him, Akiteru naturally finds it annoying. She practically lives in his room, she's always on his bed, she's just a raging storm of clinginess! Why is she only annoying around him?!
My Friend's Little Sister Has It In for Me! - Trailer
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My Friend's Little Sister Has It In for Me! - Cast & Crew
Main Cast
- Haruki Ishiya
- Sayumi Suzushiro
- Tomori Kusunoki
- Soma Saito
- Kana Hanazawa
Writers
- Touko Machida
My Friend's Little Sister Has It In for Me! - FAQs
What is My Friend's Little Sister Has It In for Me! about?
The series follows Akiteru Oboshi, a high schooler who considers friendships and romance a waste of time. His carefully guarded routine is upended when his best friend's little sister, Iroha Kohinata, takes an inexplicable interest in teasing and pestering only him, turning his everyday life into cheerful chaos.
Is My Friend's Little Sister Has It In for Me! based on a light novel?
Yes. The anime is adapted from a light novel series of the same name. The original novels were published by SB Creative under their GA Bunko imprint, blending romantic comedy and slice-of-life elements centered on the dynamic between Akiteru and the persistently annoying Iroha.
Where can you stream My Friend's Little Sister Has It In for Me!?
My Friend's Little Sister Has It In for Me! is available to stream on Crunchyroll and via the Crunchyroll Amazon Channel. It can also be purchased digitally on Amazon Video and Apple TV. Crunchyroll remains the primary streaming destination for international anime fans.
Who voices the main characters in this anime?
Haruki Ishiya voices the lead, Akiteru Oboshi, while Sayumi Suzushiro plays the irrepressible Iroha Kohinata. Tomori Kusunoki voices Mashiro Tsukinomori, Soma Saito voices Ozuma Kohinata, and the acclaimed Kana Hanazawa voices Sumire Kageishi.
How many episodes does the series have?
My Friend's Little Sister Has It In for Me! consists of 12 episodes across its single season. Each episode runs approximately 23 minutes. The series concluded in 2025, and its status is listed as Ended, with no second season officially announced at this time.
When did My Friend's Little Sister Has It In for Me! first air?
The series premiered on October 4, 2025, broadcasting across multiple Japanese TV Asahi network affiliates including HTB, Nagoya TV, KBC, and others. It was simultaneously made available internationally through Crunchyroll for viewers outside Japan.
What is the content rating for this anime series?
My Friend's Little Sister Has It In for Me! carries a TV-14 content rating in the United States, indicating it may be unsuitable for children under 14. The series contains comedic romantic situations, mild suggestive humor, and the typical antics found in harem-adjacent romantic comedy anime.
What anime is similar to My Friend's Little Sister Has It In for Me!?
Fans of this series may enjoy A Couple of Cuckoos (2022) for its similarly chaotic romantic comedy setup, Honey and Clover (2005) for its heartfelt slice-of-life tone, and Arakawa Under the Bridge (2010) for its offbeat humor. All three share themes of unexpected relationships and comedic domestic tension.
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